Molecular Pathology of Bone Tumors

Molecular pathology of oligodendroglial tumors.

The term oligodendroglioma was created by Bailey, Cushing, and Bucy based on the observation that these tumors share morphological similarities with oligodendrocytes (Bailey and Cushing 1926; Bailey and Bucy 1929). However, a convincing link between oligodendrocytes and oligodendrogliomas still needs to be shown. Oligoastrocytomas or mixed gliomas are histologically defined by the presence of o...

Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas.

Adrenal cortical carcinoma is a rare but interesting endocrine tumor. Its diagnosis is usually straightforward using morphologic assessment and supplemental immunohistochemistry. However, diagnostically challenging cases exist and pathologic evaluation would benefit from the availability of adjunctive molecular testing. Here, the relevant molecular pathology of adrenal cortical tumors is review...

Genetics of Pediatric Bone Tumors: a Systematic Review

Background: Understanding the differences in genetics of malignancies is crucial for therapeutic decisions. This systematic review was conducted to evaluate the current evidence on genetics of bone tumors in the context of pediatric cancer. Material and Methods: We performed a systematic review of the literature published on genetics of pediatrics bone tumors, using PubMed, Google scholar,...

Molecular cytogenetics of bone and soft tissue tumors.

Pathology of Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumor (GIST) is a well recognized and relatively well understood soft tissue tumor. Early events in GIST development are activating mutations in KIT or PDGFRA, which occur in most GISTs and encode for mutated tyrosine receptor kinases that are therapeutic targets for tyrosine kinase inhibitors, including imatinib and sunitinib. A small minority of GISTs possessing neith...